IL-5

• Description :

  IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Recombinant rat IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

• Synonyms :

  Il5; Il-5

• NCBI Gene ID :

  24497

• UniProt :

  Q9R2C9

• Accession Number :

  NP_068606.1

• Accession Number mRNA :

  NM_021834.1

• Chromosomal Location :

  10q22

• Reactivity :

  Rat

• Cross Reactivity :

  Human

• Sequence :

  MEIPMSTVVK ETLIQLSTHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEILFQNL SLIKKYIDGQ KEKCGEERRK TRHFLDYLQE FLGVMSTEWA MEV

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.

• Length :

  113

• Form :

  Lyophilized

• Molecular Weight :

  26 kDa

• Host or Source :

  E. coli