IL-5

• Description:

  IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Recombinant rat IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

• Synonyms:

  Il5; Il-5

• NCBI Gene ID:

  24497

• UniProt:

  Q9R2C9

• Accession Number:

  NP_068606.1

• Accession Number mRNA:

  NM_021834.1

• Chromosomal Location:

  10q22

• Reactivity:

  Rat

• Cross Reactivity:

  Human

• Sequence:

  MEIPMSTVVK ETLIQLSTHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEILFQNL SLIKKYIDGQ KEKCGEERRK TRHFLDYLQE FLGVMSTEWA MEV

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.

• Length:

  113

• Form:

  Lyophilized

• Molecular Weight:

  26 kDa

• Host or Source:

  E. coli