IL-5

• Description :

  IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

• Synonyms :

  Il5; Il-5; B-cell growth factor II; Short name=BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; T-cell replacing factor

• NCBI Gene ID :

  16191

• UniProt :

  P04401

• Accession Number :

  NP_034688.1

• Accession Number mRNA :

  NM_010558.1

• Chromosomal Location :

  11 A5/B1; 11 29.2 cM

• Reactivity :

  Mouse

• Cross Reactivity :

  Human, Mouse

• Sequence :

  MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells and is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

• Length :

  113

• Form :

  Lyophilized

• Molecular Weight :

  26.2 kDa

• Host or Source :

  E. coli