IL-3 Recombinant Protein

IL-3 Recombinant Protein

• Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
• Synonyms: Il3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu
• CAS Number: 9000-83-3
• NCBI Gene ID: 16187
• UniProt: P01586
• Accession Number: NP_034686.2
• Accession Number mRNA: NM_010556.4
• Gene Location: 11 B1; 11 28.5 cM
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Rat, Mouse, Human, Monkey, Bacteria, Gerbil
• Sequence: ASISGRDTHR LTRTLNCSSI VKEIIGKLPE PELKTDDEGP SLRNKSFRRV NLSKFVESQG EVDPEDRYVI KSNLQKLNCC LPTSANDSAL PGVFIRDLDD FRKKLRFYMV HLNDLETVLT SRPPQPASGS VSPNRGTVEC
• Detection Range: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is in the range of 20-100 pg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & Coomassie stain
• Length: 140
• Form: Lyophilized
• Buffer: PBS
• Molecular Weight: 15.8 kDa
• Shipping Conditions: Room Temperature