IL-3

• Description :

  IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

• Synonyms :

  Il3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu

• NCBI Gene ID :

  16187

• UniProt :

  P01586

• Accession Number :

  NP_034686.2

• Accession Number mRNA :

  NM_010556.4

• Chromosomal Location :

  11 B1; 11 28.5 cM

• Reactivity :

  Mouse

• Cross Reactivity :

  Rat, Mouse, Human, Monkey, Bacteria, Gerbil

• Sequence :

  ASISGRDTHR LTRTLNCSSI VKEIIGKLPE PELKTDDEGP SLRNKSFRRV NLSKFVESQG EVDPEDRYVI KSNLQKLNCC LPTSANDSAL PGVFIRDLDD FRKKLRFYMV HLNDLETVLT SRPPQPASGS VSPNRGTVEC

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & Coomassie stain

• Bioactivity :

  The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is in the range of 20-100 pg/ml.

• Length :

  140

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  Water

• Molecular Weight :

  15.8 kDa

• Host or Source :

  E. coli

• N Terminal Sequence :

  ASISGR