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IL-3

CAT: 0209-200-015-SCSize: 50 µgDry Ice: NoHazardous: No
CAT#: 200-015-SCSize: 50 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.
Synonyms
IL3; IL-3; MCGF; MULTI-CSF
NCBI Gene ID
3562
UniProt
P08700
Accession Number
NP_000579
Accession Number mRNA
NM_000588
Chromosomal Location
5q31.1
Reactivity
Human
Cross Reactivity
Human
Sequence
MAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF
Assay Protocol
The lyophilized IL-3 should be reconstituted in water to a concentration not less than 100µg/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>98% by SDS-PAGE
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is < 0.1 – 0.5 ng/ml. The WHO standard #91/510 was used as a control.
Length
134
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
15.0 kDa
Storage Conditions
The lyophilized IL-3, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted IL-3 should be stored in working aliquots at -20°C.
Host or Source
E. coli
N Terminal Sequence
MAPMTQT

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