IL-2

• Description:

  IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant rat IL-2ƒ is a 15.3 kDa protein containing 134 amino acid residues.

• Synonyms:

  RbcL

• NCBI Gene ID:

  809853

• UniProt:

  P17108

• Accession Number:

  NP_446288.1

• Accession Number mRNA:

  NM_053836.1

• Chromosomal Location:

  2q25

• Reactivity:

  Rat

• Cross Reactivity:

  Mouse, Rat

• Sequence:

  MAPTSSPAKE TQQHLEQLLL DLQVLLRGID NYKNLKLPMM LTFKFYLPKQ ATELKHLQCL ENELGALQRV LDLTQSKSFH LEDAGNFISN IRVTVVKLKG SENKFECQFD DEPATVVEFL RRWIAIAQSI ISTM

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is < 0.4 ng/ml, corresponding to a specific activity of > 2.5 x 106 units/mg.

• Length:

  134

• Form:

  Lyophilized

• Molecular Weight:

  15.3 kDa

• Host or Source:

  E. coli