IL-1 alpha Recombinant Protein

IL-1 alpha Recombinant Protein

• Description: IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1α is a 17.7 kDa protein containing 155 amino
• Synonyms: Il1a; IL-1 alpha
• CAS Number: 9000-83-3
• NCBI Gene ID: 24493
• UniProt: P16598
• Accession Number: NP_058715.1
• Accession Number mRNA: NM_017019
• Gene Location: 3q36
• Host: E. coli
• Origin Species: Rat
• Species Reactivity: Mouse, Rat
• Sequence: MAPHSFQNNL RYKLIRIVKQ EFIMNDSLNQ NIYVDMDRIH LKAASLNDLQ LEVKFDMYAY SSGGDSKYPV TLKVSNTQLF VSAQGEDKPV LLKEIPETPK LITGSETDLI FFWEKINSKN YFTSAAFPEL LIATKEQSQV HLARGLPSMI DFQIS
• Detection Range: The ED50 as determined by the dose-dependent proliferation of murine D10S cells is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 108 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 155
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Reconstitute in0.5X PBS to a concentration of 0.1-1.0mg/mL.
• Molecular Weight: 17.7 kDa
• Shipping Conditions: Room Temperature