IL-1 alpha Recombinant Protein

IL-1 alpha Recombinant Protein

• Description: IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1α is an 17.9 kDa protein containing 156 amino acid residues.
• Synonyms: Il1a; Il-1a
• CAS Number: 9000-83-3
• NCBI Gene ID: 16175
• UniProt: P01582
• Accession Number: NP_034684.2
• Accession Number mRNA: NM_010554
• Gene Location: 2F;273.0cM
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Mouse, Human, Rat
• Sequence: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS
• Detection Range: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 159
• Form: Lyophilized
• Molecular Weight: 17.9 kDa
• Shipping Conditions: Room Temperature