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IFN alpha 2a

CAT: 0209-100-446Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-446Size:100 µg
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Description
Proteins of this family play an important role in inducing non‐specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFN‐β. Both IFNs have similar anti‐viral activity and regulate expression of MHC class I antigens. IFN‐α contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant Human IFN‐α (2a) is a 19.3 kDa protein containing 166 amino acid residues.
Synonyms
Interferon alpha‐2, Interferon alpha A, Type I interferon
NCBI Gene ID
3440
UniProt
P01563
Accession Number
NP_000596.2
Accession Number mRNA
NM_000605.4
Chromosomal Location
9p21.3
Reactivity
Human
Cross Reactivity
Human
Sequence
MCDLPQTHSL GSRRTLMLLA QMRKISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by a cytotoxicity assay using human TF-1 cells.
Length
166
Form
Lyophilized
Molecular Weight
19.3 kDa
Host or Source
E. coli

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