GLP-1 Recombinant Protein

GLP-1 Recombinant Protein

• Description: GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is stimulation of pancreatic β-cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include suppression of plasma glucagons levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. Recombinant human GLP-1 is a 3.3 kDa consisting of 31 amino acid residues.
• Synonyms: GLP1; GLP2; GRPP
• CAS Number: 9000-83-3
• NCBI Gene ID: 2641
• UniProt: P01275
• Accession Number: NP_002045.1
• Accession Number mRNA: NM_002054.4
• Gene Location: 2q36-q37
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: HAEGTFTSDV SSYLEGQAAK EFIAWLVKGR G
• Detection Range: Data not available.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 31
• Form: Lyophilized
• Molecular Weight: 3.3 kDa
• Shipping Conditions: Room Temperature