Endothelin-1/ET-1 Recombinant Protein

• Description:

  Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.

• Synonyms:

  Preproendothelin-1, PPET-1, ET-1, EDN1

• NCBI Gene ID:

  1906

• UniProt:

  P05305

• Accession Number:

  NP_001946.3

• Accession Number mRNA:

  NM_01955.4

• Host:

  E. coli

• Origin Species:

  Human

• Species Reactivity:

  Human

• Target Antigen:

  Recombinant Human Endothelin-2

• Tag:

  His-Tag

• Sequence:

  MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH

• Purity:

  > 98% by SDS-PAGE & visualized Coomassie stain

• Length:

  204

• Form:

  Lyophilized from PBS

• Buffer:

  PBS

• Molecular Weight:

  26.0 kDa

• Shipping Conditions:

  Room Temperature

• CAS Number:

  9000-83-3