GDF-15/MIC-1 Recombinant Protein

GDF-15/MIC-1 Recombinant Protein

• Description: GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.
• Synonyms: GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
• CAS Number: 9000-83-3
• NCBI Gene ID: 9518
• UniProt: Q99989
• Accession Number: NP_004855.3
• Accession Number mRNA: NM_004865
• Gene Location: 19p13.11
• Host: CHO
• Origin Species: Human
• Species Reactivity: Human
• Sequence: ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
• Detection Range: Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 114
• Form: Lyophilized
• Molecular Weight: 24.6 kDa
• Shipping Conditions: Room Temperature