GDF-3 Recombinant Protein

CAT:
209-100-179S
Size:
5 µg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
GDF-3 Recombinant Protein - image 1

GDF-3 Recombinant Protein

  • Description:

    GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
  • Synonyms:

    GDF3; KFS3; MCOP7; MCOPCB6
  • NCBI Gene ID:

    9573
  • UniProt:

    Q9NR23
  • Accession Number:

    NP_065685.1
  • Accession Number mRNA:

    NM_020634
  • Gene Location:

    12p13.1
  • Host:

    E. coli
  • Origin Species:

    Human
  • Species Reactivity:

    Mouse
  • Sequence:

    AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
  • Detection Range:

    Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
  • Endotoxin:

    < 0.1 ng/µg of protein (<1EU/µg)
  • Purity:

    > 98% by SDS-PAGE & HPLC analyses
  • Length:

    114
  • Form:

    Lyophilized
  • Molecular Weight:

    26 kDa
  • Shipping Conditions:

    Room Temperature
  • CAS Number:

    9000-83-3