GDF-3 Recombinant Protein

GDF-3 Recombinant Protein

• Description: GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
• Synonyms: GDF3; KFS3; MCOP7; MCOPCB6
• CAS Number: 9000-83-3
• NCBI Gene ID: 9573
• UniProt: Q9NR23
• Accession Number: NP_065685.1
• Accession Number mRNA: NM_020634
• Gene Location: 12p13.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Mouse
• Sequence: AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
• Detection Range: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 114
• Form: Lyophilized
• Molecular Weight: 26 kDa
• Shipping Conditions: Room Temperature