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G-CSF

CAT: 0209-100-029SSize: 2 µgDry Ice: NoHazardous: No
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CAT#:0209-100-029SSize:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and mouse G-CSF are cross-species reactive. Recombinant human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues.
Synonyms
CSF3; GCSF; CSF3OS; C17orf33
NCBI Gene ID
1440
UniProt
P09919
Accession Number
NP_000750.1
Accession Number mRNA
NM_000759
Chromosomal Location
17q11.2-q12
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Pig, Human, Plant
Sequence
TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Length
174
Form
Lyophilized
Molecular Weight
18.7 kDa
Host or Source
E. coli

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