FGF-23

• Description :

  The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.

• Synonyms :

  FGF23; ADHR; HYPF; HPDR2; PHPTC ; fgf 23

• NCBI Gene ID :

  8074

• UniProt :

  Q9GZV9

• Accession Number :

  NP_065689.1

• Accession Number mRNA :

  NM_020638

• Chromosomal Location :

  12p13.3

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Recombinant human FGF-23

• Clone :

  Rabbit IgG

• Applications :

  ELISA, WB

• Purification Method :

  Antigen-affinity purified

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  Water

• Host or Source :

  Rabbit