FGF-23

• Description:

  The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.

• Synonyms:

  FGF23; ADHR; HYPF; HPDR2; PHPTC ; fgf 23

• NCBI Gene ID:

  8074

• UniProt:

  Q9GZV9

• Accession Number:

  NP_065689.1

• Accession Number mRNA:

  NM_020638

• Chromosomal Location:

  12p13.3

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human FGF-23

• Clone:

  Rabbit IgG

• Applications:

  ELISA, WB

• Purification Method:

  Antigen-affinity purified

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  Water

• Host or Source:

  Rabbit