FGF-23 Recombinant Protein

FGF-23 Recombinant Protein

• Description: The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant human FGF-23 is a 22.5 kDa globular protein containing 228 amino acid residues.
• Synonyms: FGF23; ADHR; HYPF; HPDR2; PHPTC ; fgf 23
• CAS Number: 9000-83-3
• NCBI Gene ID: 8074
• UniProt: Q9GZV9
• Accession Number: NP_065689.1
• Accession Number mRNA: NM_020638
• Gene Location: 12p13.3
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI
• Detection Range: Testing in Progress.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Length: 228
• Form: Lyophilized
• Molecular Weight: 22.5 kDa
• Shipping Conditions: Room Temperature