FGF-21 Recombinant Protein

FGF-21 Recombinant Protein

• Description: FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Recombinant human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
• Synonyms: FGF21
• CAS Number: 9000-83-3
• NCBI Gene ID: 26291
• UniProt: Q9NSA1
• Accession Number: NP_061986.1
• Accession Number mRNA: NM_019113
• Gene Location: 19q13.1-qter
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
• Detection Range: FGF-21, in the absence of betaKlotho, shows weak activity of thymidine uptake by BaF3 cells expressing FGF receptors.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 90% by SDS-PAGE & HPLC analyses
• Length: 182
• Form: Lyophilized
• Molecular Weight: 19.5 kDa
• Shipping Conditions: Room Temperature