FGF-10

• Description:

  Fibroblast Growth Factor-10 (FGF-10) is a heparin binding growth factor which stimulates the proliferation and activation of cells that express FGF receptors. FGF-10 is most related to KGF/FGF-7 and is expressed during development and preferentially in adult lungs. Human FGF-10 is a 19.3 kDa protein containing 170 amino acid residues.

• Synonyms:

  FGF10; KGF2

• NCBI Gene ID:

  2255

• UniProt:

  O15520

• Accession Number:

  NP_004456.1

• Accession Number mRNA:

  NM_004465

• Chromosomal Location:

  5p13-p12

• Reactivity:

  Human

• Cross Reactivity:

  Chicken, Mouse, Human

• Sequence:

  MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS

• Assay Protocol:

  The lyophilized FGF-10 should be reconstituted in water to a concentration not lower than 50 μg/ml. For long term storage we would recommend to add at least 0.1% human or bovine serum albumin.

• Purity:

  > 95% by SDS-PAGE

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF- receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length:

  170

• Form:

  Lyophilized

• Buffer:

  0.5xPBS

• Reconstitution:

  Water

• Molecular Weight:

  19.3 kDa

• Storage Conditions:

  Lyophilized samples are stable for more than six months at -20°C to -70°C.

• Host or Source:

  E. coli

• N Terminal Sequence:

  MLGQDM