FGF-6

• Description:

  FGF-6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.

• Synonyms:

  FGF6; HST2; HBGF-6

• NCBI Gene ID:

  2251

• UniProt:

  P10767

• Accession Number:

  NP_066276

• Accession Number mRNA:

  NM_020996

• Chromosomal Location:

  12p13

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  GTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length:

  168

• Form:

  Lyophilized

• Buffer:

  10 mM NaP, pH 7.2 + 50 mM NaCl

• Molecular Weight:

  18.7 kDa

• Host or Source:

  E. coli