Epigen

CAT: 0209-103-M379Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0209-103-M379Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Epigen (EPGN) is an epithelial mitogen that belongs to the EGF superfamily. Mouse Epigen cDNA encodes a 152 amino acid (aa) residue type I transmembrane precursor protein with a 23 aa putative signal peptide, an 86 aa extracellular domain, a 21 aa transmembrane domain and a 22 aa cytoplasmic domain. The extracellular domain (aa 24-109) contains a pattern of six cysteines typical of EGF family proteins. Epigen is among several EGF family proteins that can undergo metalloproteinase cleavage to generate a soluble form. Cleavage of Epigen by TACE/ADAM17 has been demonstrated. The mature, shed form of mouse Epigen (aa 53-103) shares 92%, 96% and 90% aa sequence identity with human, rat and equine Epigen, respectively, and more than 40% aa identity with corresponding regions of TGFα and epiregulin. Epigen mRNA is found in many tissues, but it is mainly expressed in actively proliferating cells within these tissues. For example, Epigen in skin is found mainly in the proliferating root sheath of hair follicles, and transgenic overexpression in the skin causes hyperplasia in sebaceous glands. Epigen is also expressed developmentally and by invasive adenocarcinomas of the breast and prostate. Epigen is strongly mitogenic for epithelial cells and fibroblasts, despite its relatively weak affinity for its main receptor, ErbB1. The mitogenic potential of Epigen is enhanced by its unusually long persistence on the membrane before ubiquitylation and receptor-mediated-depletion.

Synonyms

Esm1; ESM-1; AV004503; 0610042H23Rik

NCBI Gene ID

71920

UniProt

Q924X1

Accession Number

NP_444317.1

Accession Number mRNA

NM_053087.2

Chromosomal Location

5; 5 E2

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant mouse protein Epigen

Clone

(#2L47)

Applications

Purification Method

Protein G/A chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG2

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