Ephrin-B3

CAT: 0209-101-M393Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M393Size:100 µg
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Description
EphrinB3, also known as NLERK2, ElkL3, EFL6, ELF3 and LERK8, is a member of the Ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids (aa) and includes four invariant cysteines. The B class ligands are transmembrane proteins which can be tyrosine phosphorylated upon receptor ligation. The cytoplasmic domains are approximately 80 aa long and are highly conserved, especially the last 33 aa. Several signaling molecules have been shown to interact with the cytoplasmic region, although specific signaling roles have yet to be elucidated. EphrinB3 has been shown to bind EphrinA4, EphrinB1, EphrinB2, and EphrinB3. The extracellular domains of murine and human EphrinB3 share 98% aa identity. Only membranebound or Fc-clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. It has been found that nearly all the receptors and ligands are expressed in developing and adult neural tissue. The Ephrin/Eph families also appear to play a role in angiogenesis.
Synonyms
EFNB3; EFL6; EPLG8; LERK8
NCBI Gene ID
1949
UniProt
Q15768
Accession Number
NP_001397.1
Accession Number mRNA
NM_001406.3
Chromosomal Location
17p13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Ephrin-B3 EC domain
Clone
(#12X1)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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