Eotaxin-2 (CCL24)

• Description :

  Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues.

• Synonyms :

  CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24

• NCBI Gene ID :

  6369

• UniProt :

  O00175

• Accession Number :

  NP_002982.2

• Accession Number mRNA :

  NM_002991

• Chromosomal Location :

  7q11.23

• Reactivity :

  Human

• Cross Reactivity :

  Mouse, Human, Bacteria

• Sequence :

  VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml.

• Length :

  78

• Form :

  Lyophilized

• Molecular Weight :

  8.8 kDa

• Host or Source :

  E. coli