Dkk-2 Recombinant Protein
CAT:
209-200-014S
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Dkk-2 Recombinant Protein
- Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.
- Synonyms: Dickkopf-related protein-2, Dickkopf-2
- NCBI Gene ID: 22943
- UniProt: O94907
- Accession Number: NP_036374.1
- Accession Number mRNA: NM_012242.2
- Gene Location: 10q11.2
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Human
- Tag: His-Tag
- Sequence: MKLNSIKSSL GGETPGQAAN RSAGMYQGLA FGGSKKGKNL GQAYPCSSDK ECEVGRYCHS PHQGSSACMV CRRKKKRCHR DGMCCPSTRC NNGICIPVTE SILTPHIPAL DGTRHRDRNH GHYSNHDLGW QNLGRPHTKM SHIKGHEGDP CLRSSDCIEG FCCARHFWTK ICKPVLHQGE VCTKQRKKGS HGLEIFQRCD CAKGLSCKVW KDATYSSKAR LHVCQKITRL EHHHHHH
- Purity: 95% by SDS-PAGE & visualized Coomassie stain
- Length: 235
- Form: Lyophilized from PBS
- Buffer: PBS
- Molecular Weight: 26.0 kDa
- Shipping Conditions: Room Temperature