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CXCR1 (IL-8RA)

CAT: 0209-101-M360Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M360Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXCR1, also known as IL-8 RA and CD181, is an approximately 60 kDa 7TM glycoprotein that functions as a receptor for the chemokine CXCL8/IL-8. It is expressed on neutrophils, monocytes, CD8 T cells, FoxP3+ CD4 Treg cells, mast cells, neuronal and glial cells, vascular endothelial cells, and melanoma. CXCR1 forms homodimers and heterodimers with CXCR2/IL-8 RB. It can be cleaved from neutrophils in the lungs of cystic fibrosis patients to release fragments that promote CXCL8 production from airway epithelial cells. CXCR1 mediates neutrophil activation and chemotaxis to sites of inflammation as well as angiogenesis and melanoma invasiveness.
Synonyms
CXCR1; C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
NCBI Gene ID
3577
UniProt
P25024
Accession Number
NP_000625.1
Accession Number mRNA
NM_000634.2
Chromosomal Location
2q35
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant CXCR1
Clone
(#7D22)
Applications
WB, FC, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

UniProtKB · P25024

C-X-C chemokine receptor type 1

CXCR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25024
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R1, CXCR-1
EC number
—
Processing
—
Secondary accessions
B2R6Q3, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Biological process

Chemotaxis

PTM

Disulfide bondGlycoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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