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Complement Factor D (Adipsin)

CAT: 0209-101-M335Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M335Size:100 µg
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Description
Complement Factor D, also known as adipsin, is a serine protease that catalyzes the initial proteolytic step in the alternative pathway of complement. It is an exceptionally specific protease and the only known protein substrate is factor B in complex with C3.3 Factor D protease activity is regulated by reversible conformational changes, which differs from the majority of serine proteases whose regulation involves either activation by processing of the zymogens or inactivation by binding of the inhibitors.
Synonyms
CFD; DF; ADN; PFD; ADIPSIN
NCBI Gene ID
1675
UniProt
P00746
Accession Number
NP_001919.2
Accession Number mRNA
NM_001928.2
Chromosomal Location
19p13.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant Complement factor D
Clone
(#4M47)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

UniProtKB · P00746

Complement factor D

CFAD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00746
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CFD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.46
Processing
Precursor
Secondary accessions
B4DV76, Q5U5S1, Q86VJ5, Q8N4E0, Q8WZB4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Complement alternate pathwayImmunityInnate immunity

Disease

Disease variant

PTM

Disulfide bondZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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