VEGF-D

CAT: 0209-100-374-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-100-374-L500Size:500 µg
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Description
VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymph angiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Synonyms
Vascular endothelial growth factor D; FIGF; VEGFD; VEGF-D
NCBI Gene ID
2277
UniProt
O43915
Accession Number
NP_004460.1
Accession Number mRNA
NM_004469
Chromosomal Location
Xp22.31
Reactivity
Human
Cross Reactivity
Human
Sequence
FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to bind recombinant human VEGFR3/Flt-4 Fc in a functional ELISA.
Length
117
Form
Lyophilized
Molecular Weight
26.2 kDa
Host or Source
HEK 293 cells

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