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CD32 b/c

CAT: 0209-101-M197Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M197Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. In humans each group of receptors is encoded by 2 - 3 closely related genes designated A, B, and C. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Different Fc receptors can function as activators, as inhibitors, or as decoy receptors.
Synonyms
FCGR2A; CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A2
NCBI Gene ID
2212
UniProt
P31994
Accession Number
NP_003992
Accession Number mRNA
NM_004001.4
Chromosomal Location
1q23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human CD32 b/c
Clone
(#11S7)
Applications
E
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

UniProtKB · P31994

Low affinity immunoglobulin gamma Fc region receptor II-b

FCG2B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31994
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FCGR2B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IgG Fc receptor II-b
EC number
—
Processing
Precursor
Secondary accessions
A6H8N3, O95649, Q53X85, Q5VXA9, Q8NIA1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Host-virus interaction

Molecular function

IgG-binding proteinReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Disease

Proto-oncogeneSystemic lupus erythematosus

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