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CD25

CAT: 0209-103-M107Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M107Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The biological effects of interleukin 2 (IL-2) are mediated by its binding to a multi-chain cellular receptor complex. The IL-2 receptor (IL-2 R) complex consists of three glycoprotein chains. The alpha chain (IL-2 R alpha /CD25) and beta chain (IL-2 R beta /CD122) act together with the gamma chain (IL-2 R gamma /CD132) to form a high affinity receptor that transduces the signal upon IL-2 binding. Alone, IL-2 R alpha binds IL-2 with low affinity, but is unable to transduce a signal. The alpha/beta combination binds IL-2 with intermediate affinity, but is still unable to transmit a signal inside the cell. The beta/gamma complex has intermediate affinity and is capable of signaling if the concentration of IL-2 is relatively high.
Synonyms
CD25; Il2r; Ly-43; interleukin 2 receptor, alpha chain; Il2ra
NCBI Gene ID
16184
UniProt
P01590
Accession Number
NP_032393.3
Accession Number mRNA
NM_008367.3
Chromosomal Location
2 A2-A3; 2 6.4 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse CD25 protein
Clone
(#MAB0710)
Applications
IHC, FC
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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