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CD22

CAT: 0209-102-P107Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P107Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
Synonyms
CD22; SIGLEC2; SIGLEC-2
NCBI Gene ID
933
UniProt
P20273
Accession Number
NP_001762.2
Accession Number mRNA
NM_001771.3
Chromosomal Location
19q13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
CHO cells derived Recombinant Human sCD22
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

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