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CD22

CAT: 0209-102-P107Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P107Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
Synonyms
CD22; SIGLEC2; SIGLEC-2
NCBI Gene ID
933
UniProt
P20273
Accession Number
NP_001762.2
Accession Number mRNA
NM_001771.3
Chromosomal Location
19q13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
CHO cells derived Recombinant Human sCD22
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

UniProtKB · P20273

B-cell receptor CD22

CD22_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20273
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD22
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
F5GYU4, F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Ligand

Lectin

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