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Cathepsin D

CAT: 0209-101-M247Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M247Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin D is a lysosomal aspartic protease of the pepsin family (1) . Human cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (aa 1-18), a propeptide (aa 19-64), and a mature chain (aa 65-412) ) . The mature chain can be processed further to the light (aa 65-161) and heavy (aa 169-412) chains. It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
Synonyms
CTSD; CPSD; CLN10
NCBI Gene ID
1509
UniProt
P07339
Accession Number
NP_001900
Accession Number mRNA
NM_001909
Chromosomal Location
11p15.5
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Cathepsin-D
Clone
(#13P35)
Applications
Detection Ab
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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