BMP-10 Recombinant Protein

BMP-10 Recombinant Protein

• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
• Synonyms: BMP-10, Bone morphogenic protein 10
• CAS Number: 9000-83-3
• NCBI Gene ID: 27302
• UniProt: O95393
• Accession Number: NP_055297.1
• Accession Number mRNA: NM_014482.1
• Gene Location: 2p13.3
• Host: HEK 293
• Origin Species: human
• Species Reactivity: Human
• Sequence: NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR
• Detection Range: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 4.0-6.0 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: >95% by SDS-PAGE & HPLC analysis
• Length: 108
• Form: Lyophilized
• Molecular Weight: 24.4 kDa
• Shipping Conditions: Room Temperature