BMP-10

• Description:

  Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.

• Synonyms:

  BMP-10, Bone morphogenic protein 10

• NCBI Gene ID:

  27302

• UniProt:

  O95393

• Accession Number:

  NP_055297.1

• Accession Number mRNA:

  NM_014482.1

• Chromosomal Location:

  2p13.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  >95% by SDS-PAGE & HPLC analysis

• Bioactivity:

  Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 4.0-6.0 ng/ml.

• Length:

  108

• Form:

  Lyophilized

• Molecular Weight:

  24.4 kDa

• Host or Source:

  HEK293 cells