BD-2 (SAP1)

• Description :

  Human ß-defensin-2 (BD-2) is an antimicrobial peptide which belongs to the distinct family of ß-defensins. Recent studies have shown that the ß-defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Human BD-2 is a 4.3 kDa protein containing 43 amino acid residues.

• Synonyms :

  DEFB4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102

• NCBI Gene ID :

  1673

• UniProt :

  O15263

• Accession Number :

  NP_004933.1

• Accession Number mRNA :

  NM_004942.2

• Chromosomal Location :

  8p23.1

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract immature dendritic cells using a concentration of 10-100 ng/ml.

• Length :

  41

• Form :

  Lyophilized

• Molecular Weight :

  4.3 kDa

• Host or Source :

  E. coli