BD-2 (SAP1)

• Description:

  Human ß-defensin-2 (BD-2) is an antimicrobial peptide which belongs to the distinct family of ß-defensins. Recent studies have shown that the ß-defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Human BD-2 is a 4.3 kDa protein containing 43 amino acid residues.

• Synonyms:

  DEFB4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102

• NCBI Gene ID:

  1673

• UniProt:

  O15263

• Accession Number:

  NP_004933.1

• Accession Number mRNA:

  NM_004942.2

• Chromosomal Location:

  8p23.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract immature dendritic cells using a concentration of 10-100 ng/ml.

• Length:

  41

• Form:

  Lyophilized

• Molecular Weight:

  4.3 kDa

• Host or Source:

  E. coli