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4-1BBL

CAT: 0209-100-001SSize: 5 µgDry Ice: NoHazardous: No
CAT#:0209-100-001SSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.
Synonyms
TNFSF9; CD137L; 4-1BB-L
NCBI Gene ID
8744
UniProt
P41273
Accession Number
NP_003802.1
Accession Number mRNA
NM_003811.3
Chromosomal Location
19p13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
MREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 97% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The expected ED50 for this effect is 5-10 ng/ml. NOTE: Results may vary with different PBMC donors.
Length
185
Form
Lyophilized
Molecular Weight
19.5 kDa
Host or Source
E. coli

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