ADAM-10

CAT: 0209-103-M300Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-103-M300Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metallo-protease-like domain. Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Metturn expected for reprolysins, disintegrin like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97% amino acid identity between mouse, rat, bovine and human and 45% identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis. It also processes the 26 kDa membrane anchored protumor necrosis factor α (TNFα) to the 17 kDa mature TNF α. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.
Synonyms
Adam10; kuz; MADM; kuzbanian; 1700031C13Rik
NCBI Gene ID
11487
UniProt
O35598
Accession Number
NP_031425.2
Accession Number mRNA
NM_007399
Chromosomal Location
9 D; 9 41.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant protein of A Disintegrin and Metalloprotease-like Domain 10 ectodomain
Clone
(#7H12)
Applications
WB, FC, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:500-1000 (non-reducing) ; FC: 1.500-100
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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