ADAM-10

CAT: 0209-101-M205Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M205Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer’s disease.
Synonyms
ADAM10; kuz; AD10; MADM; CD156c; HsT18717
NCBI Gene ID
102
UniProt
O14672
Accession Number
NP_001101.1
Accession Number mRNA
NM_001110
Chromosomal Location
15q2; 15q22
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human ADAM-10 (extracellular domain)
Clone
(#6D31)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:500-1000
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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