Activin-A Recombinant Protein

Activin-A Recombinant Protein

• Description: Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
• Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
• CAS Number: 9000-83-3
• NCBI Gene ID: 3624
• UniProt: P08476
• Accession Number: NP_002183.1
• Accession Number mRNA: NM_002192.2
• Gene Location: 7p15-p13
• Host: CHO
• Origin Species: Human
• Species Reactivity: Human, Mouse, Rat
• Sequence: GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
• Detection Range: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Length: 116
• Form: Lyophilized
• Molecular Weight: 26.0 kDa
• Shipping Conditions: Room Temperature