Activin A Recombinant Protein

• Background:

  Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various beta subunits (betaA, betaB, betaC, and betaE in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two betaA chains. The betaA subunit can also heterodimerize with a betaB or betaC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human betaA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat betaA.

• NCBI Gene ID:

  3624

• Swiss Prot:

  P08476

• Accession Number:

  AAH07858.1

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Chemokines & Cytokines

• Buffer:

  0.056% TFA in 60% ACN

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  13 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  Inhibin, beta A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen YG., et al., 2006, Exp. Biol. Med. (Maywood) 231 (5) : 534–44.

• Background Reference 02:

  Sulyok S, et al., 2004, Mol. Cell. Endocrinol. 225 (1–2) : 127–32.

• Background Reference 03:

  Van Zonneveld P, et al., 2003, Hum Reprod 18 (3) : 495–501.

• Background Reference 04:

  Harrison, C.A. et al., 2005, Trends Endocrinol. Metab. 16:73.

• Other Product Names:

  Activin A, INHBA

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3