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Gramicidin A (TFA)

CAT: 0804-HY-P2324ASize: 1 EachDry Ice: NoHazardous: No
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Description
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) [1][2].
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gramicidin-a-tfa.html
Solubility
10 mM in DMSO
Smiles
C[C@H](NC(CNC([C@@H](NC=O)C(C)C)=O)=O)C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCCO)=O)CC1=CNC2=CC=CC=C21)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C43)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)CC(C)C)=O)CC7=CNC8=CC=CC=C87)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)C)=O)CC(C)C)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C99H140N20O17.xC2HF3O2
Molecular Weight
1882.29 (free base)
References & Citations
[1]Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020 Oct 1;11 (1) :4935.|[2]David JM, et al. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013 Nov;12 (11) :2296-307.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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