Gramicidin A

Gramicidin A

• CAS Number: 11029-61-1
• UNSPSC Description: Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α)[1][2].
• Target Antigen: Antibiotic; Bacterial; HIF/HIF Prolyl-Hydroxylase
• Type: Peptides
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/gramicidin-a.html
• Purity: 98.1
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming)
• Smiles: C[C@H](NC(CNC([C@@H](NC=O)C(C)C)=O)=O)C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCCO)=O)CC1=CNC2=CC=CC=C21)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C43)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)CC(C)C)=O)CC7=CNC8=CC=CC=C87)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)C)=O)CC(C)C)=O
• Molecular Weight: 1882.29
• References & Citations: [1]Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020 Oct 1;11(1):4935.|[2]David JM, et al. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013 Nov;12(11):2296-307.|[3]David JM, et al. Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. Mol Cancer Ther. 2014 Apr;13(4):788-99.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported