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DCBP-1

CAT: 0804-HY-134582-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134582-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression[1].
CAS Number
2484739-25-3
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dcbp-1.html
Purity
99.37
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CNC(N(CC1)CC2=C1N(N=C2N3C(C=C(C(F)F)C(C4=CN(C)N=C4)=C5)=C5CCC3)C6CCN(C(CCOCCOCCOCCOCCNC7=CC8=C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)C=C7)=O)CC6)=O
Molecular Formula
C51H63F2N11O10
Molecular Weight
1028.11
Precautions
H315, H319, H320
References & Citations
[1]Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31; S2451-9456 (20) 30513-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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