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DCB

CAT: 0804-HY-103561-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103561-01Size:5 mg
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Description
DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) . DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) [1].
CAS Number
[6971-97-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H317, H318, H335, H400, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/dcb.html
Purity
98.81
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC(/C=N/N=C/C2=CC=CC(Cl)=C2)=CC=C1
Molecular Formula
C14H10Cl2N2
Molecular Weight
277.15
Precautions
H302, H315, H317, H318, H335, H400, H410
References & Citations
[1]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64 (3) :731-40.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
MGluR5

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