DCB

• Description :

  DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) . DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H317, H318, H335, H400, H410

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dcb.html

• Purity :

  98.81

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  ClC1=CC(/C=N/N=C/C2=CC=CC(Cl)=C2)=CC=C1

• Molecular Formula :

  C14H10Cl2N2

• Molecular Weight :

  277.15

• Precautions :

  H302, H315, H317, H318, H335, H400, H410

• References & Citations :

  [1]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64 (3) :731-40.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4

• Isoform :

  MGluR5

• CAS Number :

  [6971-97-7]