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6-OAU

CAT: 0804-HY-12764-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12764-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].
CAS Number
83797-69-7
Product Name Alternative
GTPL5846
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; ERK; GPR84
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/6-OAU.html
Purity
99.77
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1NC(C=C(NCCCCCCCC)N1)=O
Molecular Formula
C12H21N3O2
Molecular Weight
239.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288 (15) :10684-91.|[2]Reyes AWB, et al. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep. 158:105079.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK

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