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Delavirdine

CAT: 0804-HY-10571-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10571-01Size:5 mg
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Description
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) . Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM) . Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1].
CAS Number
136817-59-9
Product Name Alternative
U 90152; BHAP-U 90152
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/delavirdine.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(NC1=CC=C(NC(C(N2CCN(C3=C(NC(C)C)C=CC=N3)CC2)=O)=C4)C4=C1)(C)=O
Molecular Formula
C22H28N6O3S
Molecular Weight
456.56
Precautions
H315, H319, H335
References & Citations
[1]Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37 (5) :1127-31.|[2]Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research Article
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Citation 01
Sci Rep. 2015 Oct 29;5:15806.|Future Med Chem. 2019 Feb;11 (3) :165-177.|Int J Antimicrob Agents. 2019 Dec;54 (6) :814-819.

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