RegisterLogin

CAY10499

CAT: 0804-HY-119283-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119283-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC50 values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities[1][2][3][4].
CAS Number
[359714-55-9]
Product Name Alternative
MAGL-IN-5
UNSPSC
12352005
Target
FAAH; Influenza Virus; MAGL; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/magl-in-5.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : 100 mg/mL
Smiles
O=C(OCC1=CC=CC=C1)NC2=CC=C(N3C(OC(OC)=N3)=O)C=C2C
Molecular Formula
C18H17N3O5
Molecular Weight
355.34
References & Citations
[1]Muccioli GG, et al. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem. 2008 Nov 3;9 (16) :2704-10. |[2]Granchi C, et al. 4-Aryliden-2-methyloxazol-5 (4H) -one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31 (1) :137-46.|[3]Baek YB, et al. Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus. Signal Transduct Target Ther. 2022 Oct 17;7 (1) :367.|[4]Zhuan Q, et al. Cytoplasm lipids can be modulated through hormone-sensitive lipase and are related to mitochondrial function in porcine IVM oocytes. Reprod Fertil Dev. 2020 Apr;32 (7) :667-675.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-121585-01CAY10698
HY-121537-01CAY10404
HY-121983-01CAY10594
HY-117008-01CAY10589
HY-123605-01CAY10406
HY-117617-01CAY10669
HY-13706ACAY10471
HY-118180CAY10595
HY-119973-01CAY10397
HY-119401-01CAY10444

Alternative Products

CatalogName
B7841-5CAY10499

Popular Products