Trabedersen (sodium)

• UNSPSC Description:

  Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon[1][2].

• Target Antigen:

  TGF-beta/Smad

• Type:

  Oligonucleotides

• Related Pathways:

  Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trabedersen-sodium.html

• Solubility:

  10 mM in H2O

• Smiles:

  [Trabedersen (sodium)]

• Molecular Weight:

  6174.43

• References & Citations:

  [1]Luc Vallières. Trabedersen, a TGFbeta2-specific antisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2. IDrugs. 2009 Jul;12(7):445-53.|[2]Karl-Hermann Schlingensiepen, et al. Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer. Cancer Sci. 2011 Jun;102(6):1193-200.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  Phase 3