2B- (SP) (TFA)

• Description:

  2B- (SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3) . 2B- (SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3[1].

• UNSPSC:

  12352209

• Target:

  GSK-3

• Type:

  Peptides

• Related Pathways:

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2b-sp-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N=C (N) NCCC[C@H] (N) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (N[C@@H] (C) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CO) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (NCC (N[C@@H] (COP (O) (O) =O) C (N1[C@@H] (CCC1) C (N[C@@H] (CCC (N) =O) C (N[C@H] (C (O) =O) CC (C) C) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O.O=C (O) C (F) (F) F.[x]

• Molecular Formula:

  C71H123N26O29P.xC2HF3O2

• Molecular Weight:

  1835.87 (free acid)

• References & Citations:

  [1]G I Welsh, et al. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.Anal Biochem. 1997 Jan 1;244 (1) :16-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  GSK-3α; GSK-3β