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TAT-P110

CAT: 0804-HY-P2280-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2280-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1[1].
CAS Number
2247617-97-4
Product Name Alternative
P110
UNSPSC
12352209
Target
Dynamin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tat-p110.html
Purity
99.87
Solubility
DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)
Smiles
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Molecular Formula
C100H178N44O26
Molecular Weight
2412.76
References & Citations
[1]Luis Rios, et al. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14 (1) :4356.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-OH
CAS Number2247617-97-4
PubChem CID172898033
IUPAC Name(3S)-3-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]acetyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-carbamimidamido-1-[[2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Molecular FormulaC100H178N44O26
Molecular Weight2412.8
XLogP-16.8
Topological Polar Surface Area1210
Hydrogen Bond Donor Count47
Hydrogen Bond Acceptor Count36
Rotatable Bond Count93
Heavy Atom Count170
Formal Charge0
Complexity5220
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChI
InChI=1S/C100H178N44O26/c1-52(2)43-67(89(165)143-69(44-53(3)4)92(168)144-42-16-26-71(144)91(167)141-58(20-10-36-120-95(107)108)80(156)129-50-76(151)132-70(51-145)93(169)170)142-90(166)68(46-77(152)153)131-74(149)48-126-73(148)47-128-79(155)57(19-9-35-119-94(105)106)133-84(160)62(22-12-38-122-97(111)112)137-86(162)64(24-14-40-124-99(115)116)139-88(164)66(31-32-72(104)147)140-87(163)65(25-15-41-125-100(117)118)138-85(161)63(23-13-39-123-98(113)114)136-83(159)61(18-6-8-34-102)135-82(158)60(17-5-7-33-101)134-81(157)59(21-11-37-121-96(109)110)130-75(150)49-127-78(154)56(103)45-54-27-29-55(146)30-28-54/h27-30,52-53,56-71,145-146H,5-26,31-51,101-103H2,1-4H3,(H2,104,147)(H,126,148)(H,127,154)(H,128,155)(H,129,156)(H,130,150)(H,131,149)(H,132,151)(H,133,160)(H,134,157)(H,135,158)(H,136,159)(H,137,162)(H,138,161)(H,139,164)(H,140,163)(H,141,167)(H,142,166)(H,143,165)(H,152,153)(H,169,170)(H4,105,106,119)(H4,107,108,120)(H4,109,110,121)(H4,111,112,122)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)/t56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1
InChIKey
LPSAKHDCBYBJMC-VZOPDNRXSA-N
Chemical Structure
2D Structure
2D structure of H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-OH
CAS: 2247617-97-4
CID: 172898033
Formula: C100H178N44O26
MW: 2412.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight2412.8
XLogP3-16.8
Hydrogen Bond Donor Count47
Hydrogen Bond Acceptor Count36
Rotatable Bond Count93
Exact Mass2412.3992468
Monoisotopic Mass2411.3958920
Topological Polar Surface Area1210 Ų
Heavy Atom Count170
Formal Charge0
Complexity5220
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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