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P110 heptapeptide

CAT: 0804-HY-P10368-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10368-01Size:1 mg
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Description
P110 heptapeptide is a peptide inhibitor of the Drp1-Fis1 interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of Drp1, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases[1][2][3].
CAS Number
1411976-18-5
UNSPSC
12352209
Hazard Statement
H302-H315-H319-H335
Target
Dynamin; Reactive Oxygen Species (ROS)
Type
Peptides
Related Pathways
Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/p110.html
Purity
99.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C[C@H](N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C32H56N10O11
Molecular Weight
756.85
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Luis Rios, et al. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14 (1) :4356.|[2]Liu W, et al. Brain-targeted heptapeptide-loaded exosomes attenuated ischemia-reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons. J Nanobiotechnology. 2022 May 23;20 (1) :242.|[3]Mukherjee R, et al. Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. Crit Care Med. 2022 Jun 1;50 (6) :e504-e515.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Asp-Leu-Leu-Pro-Arg-Gly-Ser-OH
CAS Number1411976-18-5
PubChem CID171902142
IUPAC Name(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Molecular FormulaC32H56N10O11
Molecular Weight756.8
XLogP-6.6
Topological Polar Surface Area351
Hydrogen Bond Donor Count11
Hydrogen Bond Acceptor Count13
Rotatable Bond Count23
Heavy Atom Count53
Formal Charge0
Complexity1340
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC(=O)O)N
InChI
InChI=1S/C32H56N10O11/c1-16(2)11-20(40-26(47)18(33)13-25(45)46)28(49)41-21(12-17(3)4)30(51)42-10-6-8-23(42)29(50)39-19(7-5-9-36-32(34)35)27(48)37-14-24(44)38-22(15-43)31(52)53/h16-23,43H,5-15,33H2,1-4H3,(H,37,48)(H,38,44)(H,39,50)(H,40,47)(H,41,49)(H,45,46)(H,52,53)(H4,34,35,36)/t18-,19-,20-,21-,22-,23-/m0/s1
InChIKey
VUAKYKPDARUALO-LLINQDLYSA-N
Chemical Structure
2D Structure
2D structure of H-Asp-Leu-Leu-Pro-Arg-Gly-Ser-OH
CAS: 1411976-18-5
CID: 171902142
Formula: C32H56N10O11
MW: 756.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight756.8
XLogP3-6.6
Hydrogen Bond Donor Count11
Hydrogen Bond Acceptor Count13
Rotatable Bond Count23
Exact Mass756.41300264
Monoisotopic Mass756.41300264
Topological Polar Surface Area351 Ų
Heavy Atom Count53
Formal Charge0
Complexity1340
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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