Vacuolin-1

CAT: 0804-HY-118630-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-118630-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells[1][2][4].

CAS Number

351986-85-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PIKfyve

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vacuolin-1.html

Purity

98.54

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1

Molecular Formula

C26H24IN7O

Molecular Weight

577.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Jan Cerny, et al.The small chemical vacuolin-1 inhibits Ca (2+) -dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep;5 (9) :883-8.|[2]Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun;590 (11) :1576-85.|[3]Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy|[4]Keerthivasan G, et al. Vesicle trafficking plays a novel role in erythroblast enucleation. Blood. 2010 Oct 28;116 (17) :3331-40.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
T21992-01	Vacuolin-1
A22213-5	Vacuolin-1 5mg
A22213-100	Vacuolin-1 100mg
A22213-50	Vacuolin-1 50mg
A22213-1	Vacuolin-1 1mg
A22213-25	Vacuolin-1 25mg
A22213-10	Vacuolin-1 10mg

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